A: In a word, Backup. Backing up your data is the best way to prevent critical data loss, and can be performed in a number of different ways. Currently, there are a number of reliable back-up systems, including CD-RW, RAID 5, disk mirroring, DAT and DLT tape drives and server replication. Each system should have a backup of some kind, with the choice being a balance between budget and value of data.
Also remember that backing up is more than just making the backup. We also recommend that if you are using tape cartridge or Zip type disks, to not re-use them for longer than six months.